Anti-Human IGFBP2 Polyclonal Antibody (HB875014)

Name: Anti-Human IGFBP2 Polyclonal Antibody
Brand: abinScience
SKU: HB875014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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Fiche technique
SDS

Aperçu

Numéro de catalogue

HB875014

Description

Anti-IGFBP2 Polyclonal Antibody (HB875014) is a rabbit polyclonal antibody detecting IGFBP2 in ELISA, IHC, WB. Suitable for Human, Bovine, Ovis aries, and Pig.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human IGFBP2 (Ala36-Gln325).

Cible

BP2, IBP-2, IGFBP2, IGF-binding protein 2, Insulin-like growth factor-binding protein 2, IGFBP-2, IBP2

Purification

Purified by antigen affinity column.

Numéro d'accès

P18065

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Insulin-like growth factor-binding protein 2 (IGFBP2) is a ~34 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation. Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif. Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury.

1. Rorive, S. et al. (2008) Glia 56, 1679-90. PMID: 18563800

2. Wang, X. et al. (2024) Apoptosis : an international journal on programmed cell death 29, 1109-1125. PMID: 38796567

3. Shen, X. et al. (2012) Molecular and cellular biology 32, 4116-30. PMID: 22869525

4. Wang, GK. et al. (2006) The Journal of biological chemistry 281, 14085-91. PMID: 16569642

5. Feng, N. et al. (2015) Journal of molecular neuroscience : MN 57, 426-34. PMID: 26076738

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human IGFBP2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human IGFBP2 Polyclonal Antibody (HB875014)

Aperçu

Images

Reférences

Fiche technique

SDS