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| カタログ番号 | HB875014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-IGFBP2 Polyclonal Antibody (HB875014) is a rabbit polyclonal antibody detecting IGFBP2 in ELISA, IHC, WB. Suitable for Human, Bovine, Ovis aries, and Pig.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IGFBP2 (Ala36-Gln325). | ||||||||
| ターゲット | BP2, IBP-2, IGFBP2, IGF-binding protein 2, Insulin-like growth factor-binding protein 2, IGFBP-2, IBP2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P18065 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Insulin-like growth factor-binding protein 2 (IGFBP2) is a ~34 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation. Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif. Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury. 1. Rorive, S. et al. (2008) Glia 56, 1679-90. PMID: 18563800 2. Wang, X. et al. (2024) Apoptosis : an international journal on programmed cell death 29, 1109-1125. PMID: 38796567 3. Shen, X. et al. (2012) Molecular and cellular biology 32, 4116-30. PMID: 22869525 4. Wang, GK. et al. (2006) The Journal of biological chemistry 281, 14085-91. PMID: 16569642 5. Feng, N. et al. (2015) Journal of molecular neuroscience : MN 57, 426-34. PMID: 26076738 | ||||||||
| 注意事項 | For research use only. |
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