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| カタログ番号 | HC001014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-IGFBP5 Polyclonal Antibody (HC001014) is a rabbit polyclonal antibody detecting Insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5; IGFBP5; IBP5 in ELISA, IHC, WB. Suitable for Human, Pig, Bovine, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human IGFBP5 (Cys30-Glu121). | ||||||||
| ターゲット | Insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5; IGFBP5; IBP5 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P24593, Q28985, Q05717, Q07079, P24594 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Insulin-like growth factor-binding protein 5 (IGFBP5) is a ~30 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells. Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells. Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling. Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs. 1. Busby, WH. et al. (2009) Osteoarthritis and cartilage 17, 547-55. PMID: 18930415 2. Jones, JI. et al. (1993) The Journal of cell biology 121, 679-87. PMID: 7683690 3. Yamaguchi, Y. et al. (2011) Journal of cellular and molecular medicine 15, 957-69. PMID: 20345844 4. Su, Y. et al. (2015) PloS one 10, e0130546. PMID: 26103640 5. Lin, W. et al. (2023) Nature communications 14, 1578. PMID: 36949068 | ||||||||
| 注意事項 | For research use only |
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