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| カタログ番号 | HV544014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-IL17F Polyclonal Antibody (HV544014) is a rabbit polyclonal antibody detecting IL17F in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IL17F (Arg31-Gln163). | ||||||||
| ターゲット | IL17F, Interleukin-17F, IL-17F, Cytokine ML-1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96PD4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Interleukin-17F (IL17F) is a ~18 kDa protein. Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation. As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. 1. Puel, A. et al. (2011) Science (New York, N.Y.) 332, 65-8. PMID: 21350122 2. Hymowitz, SG. et al. (2001) The EMBO journal 20, 5332-41. PMID: 11574464 3. Starnes, T. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 4137-40. PMID: 11591732 4. Kawaguchi, M. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 4430-5. PMID: 11591768 5. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 17911633 6. Wright, JF. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 2799-805. PMID: 18684971 7. Goepfert, A. et al. (2017) Scientific reports 7, 8906. PMID: 28827714 8. Goepfert, A. et al. (2020) Immunity 52, 499-512.e5. PMID: 32187518 | ||||||||
| 注意事項 | For research use only. |
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