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| カタログ番号 | HY229014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-IMPDH2 Polyclonal Antibody (HY229014) is a rabbit polyclonal antibody detecting IMPDH2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IMPDH2 (Asp226-Phe514). | ||||||||
| ターゲット | IMPDH-II, IMPD 2, IMPD2, IMPDH2, IMPDH 2, Inosine-5'-monophosphate dehydrogenase 2, IMP dehydrogenase 2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P12268 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) is a ~55 kDa protein. Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. 1. Hager, PW. et al. (1995) Biochemical pharmacology 49, 1323-9. PMID: 7763314 2. Carr, SF. et al. (1993) The Journal of biological chemistry 268, 27286-90. PMID: 7903306 3. McLean, JE. et al. (2004) The Biochemical journal 379, 243-51. PMID: 14766016 | ||||||||
| 注意事項 | For research use only. |
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