

| Каталожный номер | HV746014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-INVS Polyclonal Antibody (HV746014) is a rabbit polyclonal antibody detecting INVS in ELISA, IHC, WB. Suitable for Human, Mouse, and Dog.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human INVS (Met1-Lys91). | ||||||||
| Цель | INV, INVS, Inversin, Inversion of embryo turning homolog, NPHP2, Nephrocystin-2 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q9Y283 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Inversin (INVS) is a ~117 kDa protein. Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8. | ||||||||
| Примечание | For research use only. |
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