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| カタログ番号 | HB061013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||
| アプリケーション | IHC, WB | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | L24/18 | ||||
| ターゲット | Inositol-trisphosphate 3-kinase B, IP3 3-kinase B, Inositol 1, 4, 5-trisphosphate 3-kinase B, ITPKB, InsP 3-kinase B, IP3K B | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q14643,P11881,P29994 | ||||
| RRID | Anti-IP3 receptor, type 1 Antibody (L24/18) (abinScience Cat# HB061013, RRID:AB_3728178) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (ITPKB) is a ~313 kDa protein. Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix. 1. Adkins, CE. et al. (2000) The Biochemical journal 345 Pt 2, 357-63. PMID: 10620513 2. Gerber, S. et al. (2016) American journal of human genetics 98, 971-980. PMID: 27108797 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-IP3 receptor, type 1 Antibody (L24/18)
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