Anti-IRF5 Polyclonal Antibody (HC523014)

Name: Anti-IRF5 Polyclonal Antibody
Brand: abinScience
SKU: HC523014
Price: 168 USD
Availability: InStock

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Aperçu

Numéro de catalogue

HC523014

Description

Anti-IRF5 Polyclonal Antibody (HC523014) is a rabbit polyclonal antibody detecting IRF5 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human IRF5 (Glu232-Ala477).

Cible

IRF5, Interferon regulatory factor 5, IRF-5

Purification

Purified by antigen affinity column.

Numéro d'accès

Q13568

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Interferon regulatory factor 5 (IRF5) is a ~56 kDa protein. Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway. Key transcription factor regulating the IFN response during SARS-CoV-2 infection.

1. Barnes, BJ. et al. (2001) The Journal of biological chemistry 276, 23382-90. PMID: 11303025

2. Schoenemeyer, A. et al. (2005) The Journal of biological chemistry 280, 17005-12. PMID: 15695821

3. Chang Foreman, HC. et al. (2012) PloS one 7, e33098. PMID: 22412986

4. Lopez-Pelaez, M. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 17432-7. PMID: 25326418

5. Heinz, LX. et al. (2020) Nature 581, 316-322. PMID: 32433612

6. Yin, X. et al. (2021) Cell reports 34, 108628. PMID: 33440148

Note

For research use only.

Images

Reférences

Fiche technique

Anti-IRF5 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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