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| カタログ番号 | HC523014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-IRF5 Polyclonal Antibody (HC523014) is a rabbit polyclonal antibody detecting IRF5 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IRF5 (Glu232-Ala477). | ||||||||
| ターゲット | IRF5, Interferon regulatory factor 5, IRF-5 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13568 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Interferon regulatory factor 5 (IRF5) is a ~56 kDa protein. Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway. Key transcription factor regulating the IFN response during SARS-CoV-2 infection. 1. Barnes, BJ. et al. (2001) The Journal of biological chemistry 276, 23382-90. PMID: 11303025 2. Schoenemeyer, A. et al. (2005) The Journal of biological chemistry 280, 17005-12. PMID: 15695821 3. Chang Foreman, HC. et al. (2012) PloS one 7, e33098. PMID: 22412986 4. Lopez-Pelaez, M. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 17432-7. PMID: 25326418 5. Heinz, LX. et al. (2020) Nature 581, 316-322. PMID: 32433612 6. Yin, X. et al. (2021) Cell reports 34, 108628. PMID: 33440148 | ||||||||
| 注意事項 | For research use only. |
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