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| カタログ番号 | HX047014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-IRF8 Polyclonal Antibody (HX047014) is a rabbit polyclonal antibody detecting IRF8 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IRF8 (Gly128-Val426). | ||||||||
| ターゲット | Interferon regulatory factor 8, H-ICSBP, IRF-8, ICSBP1, ICSBP, IRF8, Interferon consensus sequence-binding protein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q02556 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Interferon regulatory factor 8 (IRF8) is a ~48 kDa protein. Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Can both act as a transcriptional activator or repressor. Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection. 1. Salem, S. et al. (2014) Blood 124, 1894-904. PMID: 25122610 2. Agod, Z. et al. (2018) Frontiers in immunology 9, 62. PMID: 29434592 | ||||||||
| 注意事項 | For research use only. |
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