Anti-ITK Polyclonal Antibody (HB378014)

Name: Anti-ITK Polyclonal Antibody
Brand: abinScience
SKU: HB378014
Price: 168 USD
Availability: InStock

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Спецификация:

50ug
100ug

Количество:

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Каталожный номер

HB378014

Описание

Anti-ITK Polyclonal Antibody (HB378014) is a rabbit polyclonal antibody detecting Tyrosine-protein kinase ITK/TSK; 2.7.10.2; Interleukin-2-inducible T-cell kinase; IL-2-inducible T-cell kinase; Kinase EMT; T-cell-specific kinase; Tyrosine-protein kinase Lyk; ITK; EMT; LYK in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant human ITK (Glu173-Leu620).

Цель

Tyrosine-protein kinase ITK/TSK; 2.7.10.2; Interleukin-2-inducible T-cell kinase; IL-2-inducible T-cell kinase; Kinase EMT; T-cell-specific kinase; Tyrosine-protein kinase Lyk; ITK; EMT; LYK

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

Q08881, Q03526

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Tyrosine-protein kinase ITK/TSK is a ~71 kDa protein. Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates.

1. Perez-Villar, JJ. et al. (2002) Biochemistry 41, 10732-40. PMID: 12186560

2. Grasis, JA. et al. (2003) Journal of immunology (Baltimore, Md. : 1950) 170, 3971-6. PMID: 12682224

3. Sela, M. et al. (2011) The EMBO journal 30, 3160-72. PMID: 21725281

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-ITK Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-ITK Polyclonal Antibody (HB378014)

Обзор

Изображения

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Даташит

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