Anti-IYD Polyclonal Antibody (HB478014)

Name: Anti-IYD Polyclonal Antibody
Brand: abinScience
SKU: HB478014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HB478014

Description

Anti-IYD Polyclonal Antibody (HB478014) is a rabbit polyclonal antibody detecting Iodotyrosine deiodinase 1; IYD-1; 1.21.1.1; Iodotyrosine dehalogenase 1; IYD; C6orf71; DEHAL1 in ELISA, IHC, WB. Suitable for Human, Rat, Mouse, and Pig.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant human IYD (Tyr81-Val289).

Cible

Iodotyrosine deiodinase 1; IYD-1; 1.21.1.1; Iodotyrosine dehalogenase 1; IYD; C6orf71; DEHAL1

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q6PHW0, Q5BK17, Q9DCX8, Q6TA49

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Iodotyrosine deiodinase 1 (IYD) is a ~33 kDa protein. Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine. During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT). The scavanged iodide can then reenter the hormone-producing pathways. Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine.

1. Gnidehou, S. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1574-6. PMID: 15289438

2. Moreno, JC. et al. (2008) The New England journal of medicine 358, 1811-8. PMID: 18434651

3. Hu, J. et al. (2015) The Journal of biological chemistry 290, 590-600. PMID: 25395621

4. Ingavat, N. et al. (2017) Biochemistry 56, 1130-1139. PMID: 28157283

Note

For research use only

Images

Reférences

Fiche technique

Anti-IYD Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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