Anti-JAK1 Polyclonal Antibody (HB829014)

Name: Anti-JAK1 Polyclonal Antibody
Brand: abinScience
SKU: HB829014
Price: 96 USD
Availability: InStock

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Especificación:

20ug
50ug
100ug

Número:

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Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HB829014

Descripción

Anti-JAK1 Polyclonal Antibody (HB829014) is a rabbit polyclonal antibody detecting JAK1 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human, Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human JAK1 (Pro32-Phe286).

Objetivo

JAK1B, JAK1, Janus kinase 1, Tyrosine-protein kinase JAK1, JAK1A, JAK-1

Purificación

Purified by antigen affinity column.

Número de acceso

P23458

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Tyrosine-protein kinase JAK1 is a ~133 kDa protein. Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Kinase partner for the type I interferon receptor IFNAR2. In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors.

1. Staerk, J. et al. (2005) The Journal of biological chemistry 280, 41893-9. PMID: 16239216

2. Del Bel, KL. et al. (2017) The Journal of allergy and clinical immunology 139, 2016-2020.e5. PMID: 28111307

3. Gruber, CN. et al. (2020) Immunity 53, 672-684.e11. PMID: 32750333

4. Sakatsume, M. et al. (1995) The Journal of biological chemistry 270, 17528-34. PMID: 7615558

5. Müller, M. et al. (1993) Nature 366, 129-35. PMID: 8232552

6. Simoncic, PD. et al. (2002) Current biology : CB 12, 446-53. PMID: 11909529

7. Usacheva, A. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 169, 1302-8. PMID: 12133952

8. Novick, D. et al. (1995) Journal of leukocyte biology 57, 712-8. PMID: 7759950

Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-JAK1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: PC-12 cell lysate

Referencias

Datasheet

Anti-JAK1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo