Anti-JAK1 Polyclonal Antibody (HB829014)

Name: Anti-JAK1 Polyclonal Antibody
Brand: abinScience
SKU: HB829014
Price: 96 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HB829014

説明

Anti-JAK1 Polyclonal Antibody (HB829014) is a rabbit polyclonal antibody detecting JAK1 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

種反応性

Human, Mouse

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human JAK1 (Pro32-Phe286).

ターゲット

JAK1B, JAK1, Janus kinase 1, Tyrosine-protein kinase JAK1, JAK1A, JAK-1

精製

Purified by antigen affinity column.

アクセッション番号

P23458

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Tyrosine-protein kinase JAK1 is a ~133 kDa protein. Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Kinase partner for the type I interferon receptor IFNAR2. In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors.

1. Staerk, J. et al. (2005) The Journal of biological chemistry 280, 41893-9. PMID: 16239216

2. Del Bel, KL. et al. (2017) The Journal of allergy and clinical immunology 139, 2016-2020.e5. PMID: 28111307

3. Gruber, CN. et al. (2020) Immunity 53, 672-684.e11. PMID: 32750333

4. Sakatsume, M. et al. (1995) The Journal of biological chemistry 270, 17528-34. PMID: 7615558

5. Müller, M. et al. (1993) Nature 366, 129-35. PMID: 8232552

6. Simoncic, PD. et al. (2002) Current biology : CB 12, 446-53. PMID: 11909529

7. Usacheva, A. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 169, 1302-8. PMID: 12133952

8. Novick, D. et al. (1995) Journal of leukocyte biology 57, 712-8. PMID: 7759950

注意事項

For research use only.

イメージ

Western blot

Western blot analysis was performed using anti-JAK1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: PC-12 cell lysate

参考文献

データシート

Anti-JAK1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-JAK1 Polyclonal Antibody (HB829014)

概要

イメージ

参考文献

データシート

SDS

クイックアクセス

お問い合わせ