Anti-JAK2 Polyclonal Antibody (HT091014) is a rabbit polyclonal antibody detecting JAK2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Chicken, and Pongo abelii.
Highlights
●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.
Reactivité des espèces
Human, Mouse, Rat
Applications
ELISA, IHC, WB
Espèce hôte
Rabbit
Clonalité
Polyclonal
Isotype
IgG
Immunogène
E. coli - derived recombinant Human JAK2 (Asn508-Ala800).
Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application
Dilution
ELISA
1:5000-1:20000
IHC
1:50-1:500
WB
1:500-1:2000
Stabilité et stockage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte
Tyrosine-protein kinase JAK2 is a ~130 kDa protein. Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor.
1. Greenhalgh, CJ. et al. (2005) The Journal of clinical investigation 115, 397-406. PMID: 15690087
2. Sakatsume, M. et al. (1995) The Journal of biological chemistry 270, 17528-34. PMID: 7615558
3. Oda, A. et al. (1998) Blood 92, 443-51. PMID: 9657743
4. Royer, Y. et al. (2005) The Journal of biological chemistry 280, 27251-61. PMID: 15899890
5. Saltzman, A. et al. (1998) Biochemical and biophysical research communications 246, 627-33. PMID: 9618263
6. Berry, DC. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 4340-5. PMID: 21368206
7. Guilluy, C. et al. (2010) Nature medicine 16, 183-90. PMID: 20098430
8. Jäkel, H. et al. (2011) Oncogene 30, 3502-12. PMID: 21423214
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