Anti-JAK2 Polyclonal Antibody (HT091014)

Name: Anti-JAK2 Polyclonal Antibody
Brand: abinScience
SKU: HT091014
Price: 168 USD
Availability: InStock

データシート製品共有情報コピー

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HT091014

説明

Anti-JAK2 Polyclonal Antibody (HT091014) is a rabbit polyclonal antibody detecting JAK2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Chicken, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

種反応性

Human, Mouse, Rat

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human JAK2 (Asn508-Ala800).

ターゲット

Janus kinase 2, JAK2, Tyrosine-protein kinase JAK2, JAK-2

エンドトキシンレベル

Please contact with the lab for this information.

精製

Purified by antigen affinity column.

アクセッション番号

O60674

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Tyrosine-protein kinase JAK2 is a ~130 kDa protein. Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor.

1. Greenhalgh, CJ. et al. (2005) The Journal of clinical investigation 115, 397-406. PMID: 15690087

2. Sakatsume, M. et al. (1995) The Journal of biological chemistry 270, 17528-34. PMID: 7615558

3. Oda, A. et al. (1998) Blood 92, 443-51. PMID: 9657743

4. Royer, Y. et al. (2005) The Journal of biological chemistry 280, 27251-61. PMID: 15899890

5. Saltzman, A. et al. (1998) Biochemical and biophysical research communications 246, 627-33. PMID: 9618263

6. Berry, DC. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 4340-5. PMID: 21368206

7. Guilluy, C. et al. (2010) Nature medicine 16, 183-90. PMID: 20098430

8. Jäkel, H. et al. (2011) Oncogene 30, 3502-12. PMID: 21423214

9. Dawson, MA. et al. (2009) Nature 461, 819-22. PMID: 19783980

注意事項

For research use only.

イメージ

参考文献

データシート

Anti-JAK2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-JAK2 Polyclonal Antibody (HT091014)

概要

イメージ

参考文献

データシート

SDS

クイックアクセス

お問い合わせ