Anti-JAK2 Polyclonal Antibody (HT091014) is a rabbit polyclonal antibody detecting JAK2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Chicken, and Pongo abelii.
Highlights
●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.
Реактивность видов
Human, Mouse, Rat
Применения
ELISA, IHC, WB
Хозяинский вид
Rabbit
Клоональность
Polyclonal
Изотип
IgG
Иммуноген
E. coli - derived recombinant Human JAK2 (Asn508-Ala800).
Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Информация об использовании продукта
Применение
Разбавление
ELISA
1:5000-1:20000
IHC
1:50-1:500
WB
1:500-1:2000
Устойчивость и хранение
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон
Tyrosine-protein kinase JAK2 is a ~130 kDa protein. Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor.
1. Greenhalgh, CJ. et al. (2005) The Journal of clinical investigation 115, 397-406. PMID: 15690087
2. Sakatsume, M. et al. (1995) The Journal of biological chemistry 270, 17528-34. PMID: 7615558
3. Oda, A. et al. (1998) Blood 92, 443-51. PMID: 9657743
4. Royer, Y. et al. (2005) The Journal of biological chemistry 280, 27251-61. PMID: 15899890
5. Saltzman, A. et al. (1998) Biochemical and biophysical research communications 246, 627-33. PMID: 9618263
6. Berry, DC. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 4340-5. PMID: 21368206
7. Guilluy, C. et al. (2010) Nature medicine 16, 183-90. PMID: 20098430
8. Jäkel, H. et al. (2011) Oncogene 30, 3502-12. PMID: 21423214
中文
English
한국어
日本語
Español
Français
Русский
