

| Каталожный номер | HW525014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-JAK3 Polyclonal Antibody (HW525014) is a rabbit polyclonal antibody detecting JAK3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human JAK3 (Gly46-Thr209). | ||||||||
| Цель | L-JAK, Janus kinase 3, Leukocyte janus kinase, JAK-3, Tyrosine-protein kinase JAK3, JAK3 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P52333 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Tyrosine-protein kinase JAK3 is a ~125 kDa protein. Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. | ||||||||
| Примечание | For research use only. |
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