Anti-JUN Polyclonal Antibody (HY261014)

Name: Anti-JUN Polyclonal Antibody
Brand: abinScience
SKU: HY261014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HY261014

Description

Anti-JUN Polyclonal Antibody (HY261014) is a rabbit polyclonal antibody detecting JUN in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human JUN (Met1-Phe331).

Cible

Proto-oncogene c-Jun, JUN, V-jun avian sarcoma virus 17 oncogene homolog, Transcription factor AP-1, AP1, Activator protein 1, p39

Purification

Purified by antigen affinity column.

Numéro d'accès

P05412

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Transcription factor Jun is a ~35 kDa protein. Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity. Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells.

1. Qing, J. et al. (2000) The Journal of biological chemistry 275, 38802-12. PMID: 10995748

2. Ji, Z. et al. (2012) Molecular and cellular biology 32, 385-98. PMID: 22083952

3. Baumann, S. et al. (2003) Oncogene 22, 1333-9. PMID: 12618758

4. Lan, HC. et al. (2007) Molecular and cellular biology 27, 2027-36. PMID: 17210646

5. Serra, RW. et al. (2014) eLife 3, e02313. PMID: 24623306

Note

For research use only.

Images

Reférences

Fiche technique

Anti-JUN Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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