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| カタログ番号 | HA563014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-KCNAB2 Polyclonal Antibody (HA563014) is a rabbit polyclonal antibody detecting KCNAB2 in WB, IHC, ELISA. Suitable for Human, Mouse, Rat, Dog, and Cat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | WB,IHC,ELISA | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human KCNAB2 (Gln37-Ser367). | ||||||||
| ターゲット | Voltage-gated potassium channel subunit beta-2, EC:1.1.1.-, K(+) channel subunit beta-2, Kv-beta-2, hKvbeta2, KCNAB2 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >90% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13303 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Voltage-gated potassium channel subunit beta-2, EC:1.1.1.-, K(+) channel subunit beta-2, Kv-beta-2, hKvbeta2, KCNAB2 | ||||||||
| 背景 | Voltage-gated potassium channel subunit beta-2 (KCNAB2) is a ~41 kDa protein. Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels. Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates. Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet). 1. McCormack, K. et al. (2002) The Journal of biological chemistry 277, 13219-28. PMID: 11825900 2. McCormack, K. et al. (1995) FEBS letters 370, 32-6. PMID: 7649300 | ||||||||
| 注意事項 | For research use only. |
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