

| Numéro de catalogue | HT083014 | ||||||||
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| Description |
Anti-KMO Polyclonal Antibody (HT083014) is a rabbit polyclonal antibody detecting KMO in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human KMO (Met1-Glu366). | ||||||||
| Cible | KMO, Kynurenine 3-hydroxylase, Kynurenine 3-monooxygenase | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | O15229 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Kynurenine 3-monooxygenase (KMO) is a ~55 kDa protein. Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable). 1. Amaral, M. et al. (2013) Nature 496, 382-5. PMID: 23575632 2. Mole, DJ. et al. (2016) Nature medicine 22, 202-9. PMID: 26752518 3. Hutchinson, JP. et al. (2017) Nature communications 8, 15827. PMID: 28604669 4. Gao, J. et al. (2018) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32, 2036-2045. PMID: 29208702 5. Kim, HT. et al. (2018) Cell chemical biology 25, 426-438.e4. PMID: 29429898 | ||||||||
| Note | For research use only. |
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