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| カタログ番号 | HT083014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-KMO Polyclonal Antibody (HT083014) is a rabbit polyclonal antibody detecting KMO in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human KMO (Met1-Glu366). | ||||||||
| ターゲット | KMO, Kynurenine 3-hydroxylase, Kynurenine 3-monooxygenase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15229 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Kynurenine 3-monooxygenase (KMO) is a ~55 kDa protein. Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable). 1. Amaral, M. et al. (2013) Nature 496, 382-5. PMID: 23575632 2. Mole, DJ. et al. (2016) Nature medicine 22, 202-9. PMID: 26752518 3. Hutchinson, JP. et al. (2017) Nature communications 8, 15827. PMID: 28604669 4. Gao, J. et al. (2018) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32, 2036-2045. PMID: 29208702 5. Kim, HT. et al. (2018) Cell chemical biology 25, 426-438.e4. PMID: 29429898 | ||||||||
| 注意事項 | For research use only. |
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