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| カタログ番号 | HA830014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-KMT5B Polyclonal Antibody (HA830014) is a rabbit polyclonal antibody detecting Histone-lysine N-methyltransferase KMT5B; Lysine N-methyltransferase 5B; Lysine-specific methyltransferase 5B; Suppressor of variegation 4-20 homolog 1; Su(var)4-20 homolog 1; Suv4-20h1; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; 2.1.1.362; [histone H4]-lysine20 N-methyltransferase KMT5B; 2.1.1.361; KMT5B; SUV420H1; CGI-85 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human KMT5B (Met72-Ser368). | ||||||||
| ターゲット | Histone-lysine N-methyltransferase KMT5B; Lysine N-methyltransferase 5B; Lysine-specific methyltransferase 5B; Suppressor of variegation 4-20 homolog 1; Su(var)4-20 homolog 1; Suv4-20h1; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; 2.1.1.362; [histone H4]-lysine20 N-methyltransferase KMT5B; 2.1.1.361; KMT5B; SUV420H1; CGI-85 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q4FZB7, Q3U8K7, Q29RP8, P0C2N5 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Histone-lysine N-methyltransferase KMT5B is a ~99 kDa protein. Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). 1. Wu, H. et al. (2013) FEBS letters 587, 3859-68. PMID: 24396869 2. Bromberg, KD. et al. (2017) Nature chemical biology 13, 317-324. PMID: 28114273 3. Neguembor, MV. et al. (2013) Journal of molecular cell biology 5, 294-307. PMID: 23720823 | ||||||||
| 注意事項 | For research use only |
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