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Anti-KPNA1 Polyclonal Antibody (HW602014)

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Aperçu
Numéro de catalogueHW602014
Description
Anti-KPNA1 Polyclonal Antibody (HW602014) is a rabbit polyclonal antibody detecting KPNA1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Danio rerio.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human KPNA1 (Leu239-Thr506).
Cible KPNA1, SRP1-beta, Importin subunit alpha-5, RCH2, Karyopherin subunit alpha-1, Nucleoprotein interactor 1, RAG cohort protein 2, NPI-1
Purification Purified by antigen affinity column.
Numéro d'accès P52294
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Importin subunit alpha-5 (KPNA1) is a ~60 kDa protein. Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

1. Seo, HG. et al. (2016) Scientific reports 6, 34614. PMID: 27713473
2. Moroianu, J. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 2008-11. PMID: 7892216
3. Moroianu, J. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 6572-6. PMID: 8692858
4. Yang, TJ. et al. (2022) The Journal of cell biology 221. PMID: 35446349
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-KPNA1 Polyclonal Antibody

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