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| カタログ番号 | HW602014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-KPNA1 Polyclonal Antibody (HW602014) is a rabbit polyclonal antibody detecting KPNA1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Danio rerio.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human KPNA1 (Leu239-Thr506). | ||||||||
| ターゲット | KPNA1, SRP1-beta, Importin subunit alpha-5, RCH2, Karyopherin subunit alpha-1, Nucleoprotein interactor 1, RAG cohort protein 2, NPI-1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P52294 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Importin subunit alpha-5 (KPNA1) is a ~60 kDa protein. Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. 1. Seo, HG. et al. (2016) Scientific reports 6, 34614. PMID: 27713473 2. Moroianu, J. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 2008-11. PMID: 7892216 3. Moroianu, J. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 6572-6. PMID: 8692858 4. Yang, TJ. et al. (2022) The Journal of cell biology 221. PMID: 35446349 | ||||||||
| 注意事項 | For research use only. |
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