

| Каталожный номер | HW788014 | ||||||||
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| Описание |
Anti-KPNA2 Polyclonal Antibody (HW788014) is a rabbit polyclonal antibody detecting KPNA2 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| Реактивность видов | Human, Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human KPNA2 (Ala157-Gln412). | ||||||||
| Цель | SRP1-alpha, Karyopherin subunit alpha-2, RAG cohort protein 1, RCH1, Importin subunit alpha-1, KPNA2, SRP1 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P52292 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Importin subunit alpha-1 (KPNA2) is a ~57 kDa protein. Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. 1. Zheng, W. et al. (2018) Traffic (Copenhagen, Denmark) 19, 19-28. PMID: 28991411 2. Cai, Z. et al. (2020) The Journal of experimental medicine 217. PMID: 32130408 3. Moroianu, J. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 6532-6. PMID: 7604027 4. Weis, K. et al. (1995) Science (New York, N.Y.) 268, 1049-53. PMID: 7754385 5. Yang, TJ. et al. (2022) The Journal of cell biology 221. PMID: 35446349 | ||||||||
| Примечание | For research use only. |
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