

| Número de catálogo | HY198014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-KRT18 Polyclonal Antibody (HY198014) is a rabbit polyclonal antibody detecting KRT18 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| Reactividad de especies | Human | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human KRT18 (Asp238-Leu396). | ||||||||
| Objetivo | Cytokeratin-18, CYK18, K18, Keratin, type I cytoskeletal 18, KRT18, CK-18, Keratin-18, Cell proliferation-inducing gene 46 protein | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | P05783 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Keratin, type I cytoskeletal 18 (KRT18) is a ~48 kDa protein. Required for the formation of KRT8/KRT18 filaments that are involved in ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement. Also acts downstream of ROCK kinase activation as part of a positive feedback mechanism in response to cellular mechanical stress loading. Organization and orientation of KRT18 filaments are responsible for the properly elongated morphology of epithelial tubules. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. 1. Fujiwara, S. et al. (2016) Molecular biology of the cell 27, 954-66. PMID: 26823019 | ||||||||
| Nota | For research use only. |

Western blot analysis was performed using anti-KRT18 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HT-29 cell lysate
Lane 2: Hela cell lysate
Lane 3: A431 cell lysate
Lane 4: K562 cell lysate
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