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| カタログ番号 | HB859013 | ||||
|---|---|---|---|---|---|
| アプリケーション | IHC, WB | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | K14/16 | ||||
| ターゲット | Voltage-gated K(+) channel HuKIV, Voltage-gated potassium channel subunit Kv1.2, NGK1, KCNA2, Potassium voltage-gated channel subfamily A member 2, Voltage-gated potassium channel HBK5 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P16389 | ||||
| RRID | Anti-Kv1.2 K+ channel Antibody (K14/16) (abinScience Cat# HB859013, RRID:AB_3728139) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Potassium voltage-gated channel subfamily A member 2 (KCNA2/Kv1.2 K+ channel) is a ~56 kDa protein. Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. 1. Imbrici, P. et al. (2000) Pflugers Archiv : European journal of physiology 441, 257-62. PMID: 11211111 2. Ramaswami, M. et al. (1990) Molecular and cellular neurosciences 1, 214-23. PMID: 19912772 3. Lee, JH. et al. (2013) Neuroscience letters 548, 143-8. PMID: 23769686 4. Po, S. et al. (1993) Circulation research 72, 1326-36. PMID: 8495559 5. Chen, P. et al. (2010) The Journal of biological chemistry 285, 14882-14889. PMID: 20220134 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Kv1.2 K+ channel Antibody (K14/16)
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