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| カタログ番号 | HB352014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-LCP2 Polyclonal Antibody (HB352014) is a rabbit polyclonal antibody detecting Lymphocyte cytosolic protein 2; SH2 domain-containing leukocyte protein of 76 kDa; SLP-76 tyrosine phosphoprotein; SLP76; LCP2 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human LCP2 (Pro408-Pro533). | ||||||||
| ターゲット | Lymphocyte cytosolic protein 2; SH2 domain-containing leukocyte protein of 76 kDa; SLP-76 tyrosine phosphoprotein; SLP76; LCP2 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13094, Q60787 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Lymphocyte cytosolic protein 2 (LCP2) is a ~60 kDa protein. Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells. Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK. In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation. Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses. 1. Herndon, TM. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 166, 5654-64. PMID: 11313406 2. Soini, L. et al. (2021) FEBS letters 595, 404-414. PMID: 33159816 3. Wu, J. et al. (1996) Immunity 4, 593-602. PMID: 8673706 4. Bubeck Wardenburg, J. et al. (1996) The Journal of biological chemistry 271, 19641-4. PMID: 8702662 5. Yan, Z. et al. (2021) Nature communications 12, 308. PMID: 33436632 | ||||||||
| 注意事項 | For research use only |
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