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| カタログ番号 | HX858014 | ||||||||
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| 説明 |
Anti-LOXL3 Polyclonal Antibody (HX858014) is a rabbit polyclonal antibody detecting LOXL3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Danio rerio.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human LOXL3 (Thr519-Asn726). | ||||||||
| ターゲット | Lysyl oxidase homolog 3, LOXL3, LOXL, Lysyl oxidase-like protein 3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P58215 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Lysyl oxidase homolog 3 (LOXL3) is a ~83 kDa protein. Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins. Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin. Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated. 1. Lee, JE. et al. (2006) The Journal of biological chemistry 281, 37282-90. PMID: 17018530 2. Ma, L. et al. (2017) Molecular cell 65, 296-309. PMID: 28065600 | ||||||||
| 注意事項 | For research use only. |
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