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| カタログ番号 | HC675014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-LRP8 Polyclonal Antibody (HC675014) is a rabbit polyclonal antibody detecting LRP8 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human LRP8 (Pro447-Ile675). | ||||||||
| ターゲット | LRP8, LRP-8, Low-density lipoprotein receptor-related protein 8, APOER2, Apolipoprotein E receptor 2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q14114 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Low-density lipoprotein receptor-related protein 8 (LRP8) is a ~105 kDa protein. Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. 1. Andersen, OM. et al. (2003) Biochemistry 42, 9355-64. PMID: 12899622 2. Li, X. et al. (2003) Biochemistry 42, 10406-17. PMID: 12950167 3. Yasui, N. et al. (2010) Structure (London, England : 1993) 18, 320-31. PMID: 20223215 4. Dlugosz, P. et al. (2019) Frontiers in molecular neuroscience 12, 53. PMID: 30873003 5. Lutters, BC. et al. (2003) The Journal of biological chemistry 278, 33831-8. PMID: 12807892 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-LRP8 polyclonal antibody at 1ug/mL on various samples.
Lane 1: SH-SY5Y cell lysate
Lane 2: Mouse brain lysate
Lane 3: Mouse testis lysate
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