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| カタログ番号 | VK765034 | ||||
|---|---|---|---|---|---|
| 説明 |
Anti-MACV Z Polyclonal Antibody (VK765034) is a rabbit polyclonal antibody detecting MACV Z in ELISA, IHC, WB. Suitable for Tacaribe virus and Machupo virus.
Highlights
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| 種反応性 | Junin mammarenavirus (JUNV) (Junn mammarenavirus), Machupo virus (MACV) | ||||
| アプリケーション | ELISA, IHC, WB | ||||
| 宿主種 | Rabbit | ||||
| クローン性 | Polyclonal | ||||
| アイソタイプ | IgG | ||||
| 免疫原 | E. coli - derived recombinant MACV Z (Gln15-Pro94). | ||||
| ターゲット | Z protein, Z protein | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 精製 | Purified by antigen affinity column. | ||||
| アクセッション番号 | Q88470, Q6IVU5, Q6IUF9 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | RING finger protein Z is a ~10 kDa protein. Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L. Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z. 1. Jácamo, R. et al. (2003) Journal of virology 77, 10383-93. PMID: 12970423 | ||||
| 注意事項 | For research use only |
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