Anti-MANF Polyclonal Antibody (HX175014)

Name: Anti-MANF Polyclonal Antibody
Brand: abinScience
SKU: HX175014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HX175014

Description

Anti-MANF Polyclonal Antibody (HX175014) is a rabbit polyclonal antibody detecting MANF in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human MANF (Gly28-Leu182).

Cible

ARP, ARMET, MANF, Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET

Purification

Purified by antigen affinity column.

Numéro d'accès

P55145

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a ~20 kDa protein. Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions.

1. Petrova, P. et al. (2003) Journal of molecular neuroscience : MN 20, 173-88. PMID: 12794311

2. Apostolou, A. et al. (2008) Experimental cell research 314, 2454-67. PMID: 18561914

3. Glembotski, CC. et al. (2012) The Journal of biological chemistry 287, 25893-904. PMID: 22637475

4. Bai, M. et al. (2018) Nature communications 9, 897. PMID: 29497057

5. Kovaleva, V. et al. (2023) Cell reports 42, 112066. PMID: 36739529

Note

For research use only.

Images

Reférences

Fiche technique

Anti-MANF Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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