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| カタログ番号 | HX175014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-MANF Polyclonal Antibody (HX175014) is a rabbit polyclonal antibody detecting MANF in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MANF (Gly28-Leu182). | ||||||||
| ターゲット | ARP, ARMET, MANF, Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P55145 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a ~20 kDa protein. Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. 1. Petrova, P. et al. (2003) Journal of molecular neuroscience : MN 20, 173-88. PMID: 12794311 2. Apostolou, A. et al. (2008) Experimental cell research 314, 2454-67. PMID: 18561914 3. Glembotski, CC. et al. (2012) The Journal of biological chemistry 287, 25893-904. PMID: 22637475 4. Bai, M. et al. (2018) Nature communications 9, 897. PMID: 29497057 5. Kovaleva, V. et al. (2023) Cell reports 42, 112066. PMID: 36739529 | ||||||||
| 注意事項 | For research use only. |
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