Anti-MAP2K2 Polyclonal Antibody (HW411014)

Name: Anti-MAP2K2 Polyclonal Antibody
Brand: abinScience
SKU: HW411014
Price: 168 USD
Availability: InStock

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Reférences
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SDS

Aperçu

Numéro de catalogue

HW411014

Description

Anti-MAP2K2 Polyclonal Antibody (HW411014) is a rabbit polyclonal antibody detecting MAP2K2 in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Cricetulus griseus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human MAP2K2 (Val86-Pro331).

Cible

MAP kinase kinase 2, MAPK/ERK kinase 2, ERK activator kinase 2, MAPKK 2, PRKMK2, MAP2K2, MEK 2, MEK2, MKK2, Dual specificity mitogen-activated protein kinase kinase 2

Purification

Purified by antigen affinity column.

Numéro d'accès

P36507

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) is a ~44 kDa protein. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation.

1. Lavoie, H. et al. (2018) Nature 554, 549-553. PMID: 29433126

Note

For research use only.

Images

Reférences

Fiche technique

Anti-MAP2K2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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