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| カタログ番号 | HT186014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-MAP2K7 Polyclonal Antibody (HT186014) is a rabbit polyclonal antibody detecting MAP2K7 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MAP2K7 (Thr103-Arg419). | ||||||||
| ターゲット | SAPKK4, JNK-activating kinase 2, MAPK/ERK kinase 7, MAPKK 7, c-Jun N-terminal kinase kinase 2, JNKK2, SAPK kinase 4, MEK 7, MAP kinase kinase 7, SKK4, PRKMK7, Dual specificity mitogen-activated protein kinase kinase 7, Stress-activated protein kinase kinase 4, JNK kinase 2, MKK7, MAP2K7, MEK7, JNKK 2, SAPKK-4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O14733 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) is a ~47 kDa protein. Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. 1. Huang, YA. et al. (2017) Cell 168, 427-441.e21. PMID: 28111074 | ||||||||
| 注意事項 | For research use only. |
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