

| Каталожный номер | HA232014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-MAP3K14 Polyclonal Antibody (HA232014) is a rabbit polyclonal antibody detecting MAP3K14 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant MAP3K14 (Ser332-Ser663). | ||||||||
| Цель | Mitogen-activated protein kinase kinase kinase 14, EC:2.7.11.25, NF-kappa-beta-inducing kinase, HsNIK, Serine/threonine-protein kinase NIK, MAP3K14, NIK | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q99558, Q9WUL6 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) is a ~104 kDa protein. Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway. Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response. Could act in a receptor-selective manner. 1. Willmann, KL. et al. (2014) Nature communications 5, 5360. PMID: 25406581 2. Schlechter, N. et al. (2017) Frontiers in immunology 8, 1624. PMID: 29230214 | ||||||||
| Примечание | For research use only |
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