Anti-MAP3K7 Polyclonal Antibody (HT050014)

Name: Anti-MAP3K7 Polyclonal Antibody
Brand: abinScience
SKU: HT050014
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

Número:

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Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HT050014

Descripción

Anti-MAP3K7 Polyclonal Antibody (HT050014) is a rabbit polyclonal antibody detecting MAP3K7 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human MAP3K7 (Glu30-Thr285).

Objetivo

Mitogen-activated protein kinase kinase kinase 7, TAK1, MAP3K7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

O43318

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) is a ~67 kDa protein. Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1).

1. Ninomiya-Tsuji, J. et al. (1999) Nature 398, 252-6. PMID: 10094049

2. Wang, C. et al. (2001) Nature 412, 346-51. PMID: 11460167

3. Edlund, S. et al. (2003) Molecular biology of the cell 14, 529-44. PMID: 12589052

4. Thiefes, A. et al. (2006) EMBO reports 7, 838-44. PMID: 16845370

5. Huangfu, WC. et al. (2006) The Journal of biological chemistry 281, 28802-10. PMID: 16893890

6. Pertel, T. et al. (2011) Nature 472, 361-5. PMID: 21512573

7. Moriguchi, T. et al. (1996) The Journal of biological chemistry 271, 13675-9. PMID: 8663074

8. Shirakabe, K. et al. (1997) The Journal of biological chemistry 272, 8141-4. PMID: 9079627

9. Ma, M. et al. (2023) Molecular cell 83, 3885-3903.e5. PMID: 37832545

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-MAP3K7 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo