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| カタログ番号 | HT050014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-MAP3K7 Polyclonal Antibody (HT050014) is a rabbit polyclonal antibody detecting MAP3K7 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pongo abelii.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MAP3K7 (Glu30-Thr285). | ||||||||
| ターゲット | Mitogen-activated protein kinase kinase kinase 7, TAK1, MAP3K7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O43318 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) is a ~67 kDa protein. Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1). 1. Ninomiya-Tsuji, J. et al. (1999) Nature 398, 252-6. PMID: 10094049 2. Wang, C. et al. (2001) Nature 412, 346-51. PMID: 11460167 3. Edlund, S. et al. (2003) Molecular biology of the cell 14, 529-44. PMID: 12589052 4. Thiefes, A. et al. (2006) EMBO reports 7, 838-44. PMID: 16845370 5. Huangfu, WC. et al. (2006) The Journal of biological chemistry 281, 28802-10. PMID: 16893890 6. Pertel, T. et al. (2011) Nature 472, 361-5. PMID: 21512573 7. Moriguchi, T. et al. (1996) The Journal of biological chemistry 271, 13675-9. PMID: 8663074 8. Shirakabe, K. et al. (1997) The Journal of biological chemistry 272, 8141-4. PMID: 9079627 9. Ma, M. et al. (2023) Molecular cell 83, 3885-3903.e5. PMID: 37832545 | ||||||||
| 注意事項 | For research use only. |
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