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| カタログ番号 | HS729014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-MAPK11 Polyclonal Antibody (HS729014) is a rabbit polyclonal antibody detecting MAPK11 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MAPK11 (Leu24-Phe308). | ||||||||
| ターゲット | MAP kinase 11, Mitogen-activated protein kinase p38 beta, MAPK 11, Mitogen-activated protein kinase 11, PRKM11, SAPK2B, Stress-activated protein kinase 2b, MAP kinase p38 beta, MAPK11, p38b, p38-2, SAPK2, SAPK2b | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q15759 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Mitogen-activated protein kinase 11 (MAPK11) is a ~41 kDa protein. Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. 1. Shi, Y. et al. (2002) Biological chemistry 383, 1519-36. PMID: 12452429 2. Cuadrado, A. et al. (2010) The Biochemical journal 429, 403-17. PMID: 20626350 3. Robinson, KS. et al. (2022) Science (New York, N.Y.) 377, 328-335. PMID: 35857590 4. Deak, M. et al. (1998) The EMBO journal 17, 4426-41. PMID: 9687510 5. Scheper, GC. et al. (2001) Molecular and cellular biology 21, 743-54. PMID: 11154262 | ||||||||
| 注意事項 | For research use only. |
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