Anti-MAPK14 Polyclonal Antibody (HS804014)

Name: Anti-MAPK14 Polyclonal Antibody
Brand: abinScience
SKU: HS804014
Price: 168 USD
Availability: InStock

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Каталожный номер

HS804014

Описание

Anti-MAPK14 Polyclonal Antibody (HS804014) is a rabbit polyclonal antibody detecting MAPK14 in ELISA, IHC, WB. Suitable for Dog, Cyprinus carpio, Danio rerio, Human, and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human MAPK14 (Met1-Ser360).

Цель

Stress-activated protein kinase 2a, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase p38 alpha, SAPK2A, Cytokine suppressive anti-inflammatory drug-binding protein, CSBP, CSPB1, MAP kinase 14, MAP kinase MXI2, MAPK14, CSBP2, MAP kinase p38 alpha, MAPK 14, MXI2, CSAID-binding protein, MAX-interacting protein 2, CSBP1, SAPK2a

Очистка

Purified by antigen affinity column.

Номер доступа

Q16539

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Mitogen-activated protein kinase 14 (MAPK14) is a ~41 kDa protein. Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1.

1. Deak, M. et al. (1998) The EMBO journal 17, 4426-41. PMID: 9687510

2. Pierrat, B. et al. (1998) The Journal of biological chemistry 273, 29661-71. PMID: 9792677

3. Scheper, GC. et al. (2001) Molecular and cellular biology 21, 743-54. PMID: 11154262

4. Sayed, M. et al. (2000) The Journal of biological chemistry 275, 16569-73. PMID: 10747897

5. Khurana, A. et al. (2006) The Journal of biological chemistry 281, 35316-26. PMID: 17003045

6. Webber, JL. et al. (2010) The EMBO journal 29, 27-40. PMID: 19893488

7. Zwang, Y. et al. (2006) The EMBO journal 25, 4195-206. PMID: 16932740

8. Xu, P. et al. (2010) Molecular cell 37, 551-66. PMID: 20188673

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-MAPK14 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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