Anti-MCTS1 Polyclonal Antibody (HV818014)

Name: Anti-MCTS1 Polyclonal Antibody
Brand: abinScience
SKU: HV818014
Price: 168 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HV818014

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human MCTS1 (Met1-Lys181).

Objetivo

MCTS1, Multiple copies T-cell malignancies, MCT1, MCT-1, Malignant T-cell-amplified sequence 1

Purificación

Purified by antigen affinity column.

Número de acceso

Q9ULC4

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Malignant T-cell-amplified sequence 1 (MCTS1) is a ~20 kDa protein. Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation.

1. Reinert, LS. et al. (2006) Cancer research 66, 8994-9001. PMID: 16982740

2. Skabkin, MA. et al. (2010) Genes & development 24, 1787-801. PMID: 20713520

3. Bohlen, J. et al. (2023) Cell 186, 5114-5134.e27. PMID: 37875108

4. Dierov, J. et al. (1999) Journal of cellular biochemistry 74, 544-50. PMID: 10440924

5. Herbert, GB. et al. (2001) Oncogene 20, 6777-83. PMID: 11709712

6. Shi, B. et al. (2003) Blood 102, 297-302. PMID: 12637315

7. Hsu, HL. et al. (2005) Oncogene 24, 4956-64. PMID: 15897892

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-MCTS1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo