Anti-MCU Polyclonal Antibody (HV663014)

Name: Anti-MCU Polyclonal Antibody
Brand: abinScience
SKU: HV663014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Vista general

Número de catálogo

HV663014

Descripción

Anti-MCU Polyclonal Antibody (HV663014) is a rabbit polyclonal antibody detecting MCU in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human MCU (Val51-Thr233).

Objetivo

HsMCU, Calcium uniporter protein, mitochondrial, C10orf42, CCDC109A, Coiled-coil domain-containing protein 109A, MCU

Purificación

Purified by antigen affinity column.

Número de acceso

Q8NE86

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Calcium uniporter protein, mitochondrial (MCU) is a ~39 kDa protein. Channel-forming and calcium-conducting subunit of the mitochondrial inner membrane calcium uniporter complex (uniplex), which mediates calcium uptake into the mitochondrial matrix. MCU channel activity is regulated by the calcium-sensor subunits of the uniplex MICU1 and MICU2 (or MICU3). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells.

1. Baughman, JM. et al. (2011) Nature 476, 341-5. PMID: 21685886

2. De Stefani, D. et al. (2011) Nature 476, 336-40. PMID: 21685888

3. Drago, I. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 12986-91. PMID: 22822213

4. Tarasov, AI. et al. (2012) PloS one 7, e39722. PMID: 22829870

5. Alam, MR. et al. (2012) The Journal of biological chemistry 287, 34445-54. PMID: 22904319

6. Mallilankaraman, K. et al. (2012) Cell 151, 630-44. PMID: 23101630

7. Mallilankaraman, K. et al. (2012) Nature cell biology 14, 1336-43. PMID: 23178883

8. Chaudhuri, D. et al. (2013) eLife 2, e00704. PMID: 23755363

9. Hoffman, NE. et al. (2013) Cell reports 5, 1576-1588. PMID: 24332854

10. Patron, M. et al. (2014) Molecular cell 53, 726-37. PMID: 24560927

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-MCU Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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