Anti-MCU Polyclonal Antibody (HV663014)

Name: Anti-MCU Polyclonal Antibody
Brand: abinScience
SKU: HV663014
Price: 168 USD
Availability: InStock

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Aperçu

Numéro de catalogue

HV663014

Description

Anti-MCU Polyclonal Antibody (HV663014) is a rabbit polyclonal antibody detecting MCU in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human MCU (Val51-Thr233).

Cible

HsMCU, Calcium uniporter protein, mitochondrial, C10orf42, CCDC109A, Coiled-coil domain-containing protein 109A, MCU

Purification

Purified by antigen affinity column.

Numéro d'accès

Q8NE86

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Calcium uniporter protein, mitochondrial (MCU) is a ~39 kDa protein. Channel-forming and calcium-conducting subunit of the mitochondrial inner membrane calcium uniporter complex (uniplex), which mediates calcium uptake into the mitochondrial matrix. MCU channel activity is regulated by the calcium-sensor subunits of the uniplex MICU1 and MICU2 (or MICU3). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells.

1. Baughman, JM. et al. (2011) Nature 476, 341-5. PMID: 21685886

2. De Stefani, D. et al. (2011) Nature 476, 336-40. PMID: 21685888

3. Drago, I. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 12986-91. PMID: 22822213

4. Tarasov, AI. et al. (2012) PloS one 7, e39722. PMID: 22829870

5. Alam, MR. et al. (2012) The Journal of biological chemistry 287, 34445-54. PMID: 22904319

6. Mallilankaraman, K. et al. (2012) Cell 151, 630-44. PMID: 23101630

7. Mallilankaraman, K. et al. (2012) Nature cell biology 14, 1336-43. PMID: 23178883

8. Chaudhuri, D. et al. (2013) eLife 2, e00704. PMID: 23755363

9. Hoffman, NE. et al. (2013) Cell reports 5, 1576-1588. PMID: 24332854

10. Patron, M. et al. (2014) Molecular cell 53, 726-37. PMID: 24560927

Note

For research use only.

Images

Reférences

Fiche technique

Anti-MCU Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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