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| カタログ番号 | HV663014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-MCU Polyclonal Antibody (HV663014) is a rabbit polyclonal antibody detecting MCU in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MCU (Val51-Thr233). | ||||||||
| ターゲット | HsMCU, Calcium uniporter protein, mitochondrial, C10orf42, CCDC109A, Coiled-coil domain-containing protein 109A, MCU | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q8NE86 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Calcium uniporter protein, mitochondrial (MCU) is a ~39 kDa protein. Channel-forming and calcium-conducting subunit of the mitochondrial inner membrane calcium uniporter complex (uniplex), which mediates calcium uptake into the mitochondrial matrix. MCU channel activity is regulated by the calcium-sensor subunits of the uniplex MICU1 and MICU2 (or MICU3). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. 1. Baughman, JM. et al. (2011) Nature 476, 341-5. PMID: 21685886 2. De Stefani, D. et al. (2011) Nature 476, 336-40. PMID: 21685888 3. Drago, I. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 12986-91. PMID: 22822213 4. Tarasov, AI. et al. (2012) PloS one 7, e39722. PMID: 22829870 5. Alam, MR. et al. (2012) The Journal of biological chemistry 287, 34445-54. PMID: 22904319 6. Mallilankaraman, K. et al. (2012) Cell 151, 630-44. PMID: 23101630 7. Mallilankaraman, K. et al. (2012) Nature cell biology 14, 1336-43. PMID: 23178883 8. Chaudhuri, D. et al. (2013) eLife 2, e00704. PMID: 23755363 9. Hoffman, NE. et al. (2013) Cell reports 5, 1576-1588. PMID: 24332854 10. Patron, M. et al. (2014) Molecular cell 53, 726-37. PMID: 24560927 | ||||||||
| 注意事項 | For research use only. |
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