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| カタログ番号 | HT318014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-MDM4 Polyclonal Antibody (HT318014) is a rabbit polyclonal antibody detecting MDM4 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MDM4 (Thr2-Asp134). | ||||||||
| ターゲット | MDM4, Mdm2-like p53-binding protein, MDMX, p53-binding protein Mdm4, Protein Mdm4, Protein Mdmx, Double minute 4 protein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15151 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Protein Mdm4 is a ~54 kDa protein. Contributes to p53/TP53 regulation. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding their transcriptional activation domains. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. 1. Toufektchan, E. et al. (2020) Science advances 6, eaay3511. PMID: 32300648 | ||||||||
| 注意事項 | For research use only. |
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