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| カタログ番号 | HF769014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-MFN2 Polyclonal Antibody (HF769014) is a rabbit polyclonal antibody detecting MFN2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MFN2 (His20-Arg400). | ||||||||
| ターゲット | Transmembrane GTPase MFN2, Mitofusin-2, KIAA0214, CPRP1, MFN2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95140 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Mitofusin-2 (MFN2) is a ~86 kDa protein. Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. 1. Santel, A. et al. (2001) Journal of cell science 114, 867-74. PMID: 11181170 2. Rojo, M. et al. (2002) Journal of cell science 115, 1663-74. PMID: 11950885 3. Casasnovas, C. et al. (2010) Journal of medical genetics 47, 249-56. PMID: 19889647 4. Senyilmaz, D. et al. (2015) Nature 525, 124-8. PMID: 26214738 5. Cao, YL. et al. (2017) Nature 542, 372-376. PMID: 28114303 6. Chen, Y. et al. (2013) Science (New York, N.Y.) 340, 471-5. PMID: 23620051 | ||||||||
| 注意事項 | For research use only. |
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