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| カタログ番号 | HV353014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-MIB1 Polyclonal Antibody (HV353014) is a rabbit polyclonal antibody detecting MIB1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Xenopus laevis.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MIB1 (Arg769-Glu1000). | ||||||||
| ターゲット | Zinc finger ZZ type with ankyrin repeat domain protein 2, MIB1, DIP-1, Mind bomb homolog 1, ZZANK2, DAPK-interacting protein 1, E3 ubiquitin-protein ligase MIB1, KIAA1323, DIP1, RING-type E3 ubiquitin transferase MIB1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q86YT6 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | E3 ubiquitin-protein ligase MIB1 is a ~110 kDa protein. E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. | ||||||||
| 注意事項 | For research use only. |
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