Anti-Monkey CD3 epsilon Recombinant Antibody (SAA2707) (HD679107)

Name: Anti-Monkey CD3 epsilon Recombinant Antibody (SAA2707)
Brand: abinScience
SKU: HD679107
Price: 191 USD
Availability: InStock

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Каталожный номер	HD679107
Бренд	abinScience
Реактивность видов	Monkey
Применения	ELISA, FCM
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG2a
ID клона	SAA2707
Цель	CD3E, CD3e, T-cell surface glycoprotein CD3 epsilon chain
Уровень эндотоксинов	<10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q95LI5
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	T-cell surface glycoprotein CD3 epsilon chain (CD3E) is a ~22 kDa protein. Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3E ITAM phosphorylation creates docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. CD3E is the therapeutic target of blinatumomab (Blincyto).
Примечание	For research use only

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Anti-Monkey CD3 epsilon Recombinant Antibody (SAA2707).pdf

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