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Обзор
Каталожный номерMD632014
Описание
Anti-Mouse ADGRV1 Polyclonal Antibody (MD632014) is a rabbit polyclonal antibody detecting ADGRV1. Suitable for Mouse.
Реактивность видовMouse
ПримененияELISA, IHC, WB
Хозяинский видRabbit
КлоональностьPolyclonal
ИзотипIgG
Иммуноген E. coli - derived recombinant Mouse ADGRV1 (Gly28-Asp386).
Цель ADGRV1, ADGRV1 subunit alpha, ADGRV1 subunit beta, Adgrv1, Adhesion G-protein coupled receptor V1, EC:3.4.-.-, G-protein coupled receptor 98, Gpr98, Kiaa0686, MASS1, Mass1, Monogenic audiogenic seizure susceptibility protein 1, Neurepin, Protein rueda, VLGR1, VLGR1 subunit beta, Vbeta, Very large G-protein coupled receptor 1, Vlgr1
Уровень эндотоксинов Please contact with the lab for this information.
Очистка Purified by antigen affinity column.
Номер доступа Q8VHN7
Форма Liquid
Буфер хранения 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта
Применение Разбавление
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Фон

Adhesion G-protein coupled receptor V1 (ADGRV1) is a ~687 kDa protein. G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.

1. McGee, J. et al. (2006) The Journal of neuroscience : the official journal of the Society for Neuroscience 26, 6543-53. PMID: 16775142
2. Michalski, N. et al. (2007) The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 6478-88. PMID: 17567809
3. Yang, J. et al. (2010) PLoS genetics 6, e1000955. PMID: 20502675
4. Shin, D. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 19101-6. PMID: 24191038
5. Hu, QX. et al. (2014) The Journal of biological chemistry 289, 24215-25. PMID: 24962568
Примечание For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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